Development of analytical science research equipment (BIG Project) will be performed to secure core technology for research equipment and contribute to the development of the domestic research equipment industry. We selected seven types of entrylevel, leading-level, and pioneering-level to secure infrastructure and core technologies. The Scientific instrument reliability assessment center (SIRAC) has been established to build the reliability evaluation system for domestic research equipment. The Use laboratory in SIRAC will contribute to the improvement of the reliability of domestic research equipment through comparison, evaluation, diagnosis, improvement, and support.