X-ray and Cryo-EM Research Unit
- Support for national research in the field of structural biology based on the integrated operation of X-ray crystallography and Cryo-Electron Microscopy (Cryo-EM)
- Analysis of functions and mechanisms of action based on high-resolution three-dimensional structures of biomolecules
- Support for collaborative research in structure-based drug development and the bioindustry
Research Content
A unified X-ray and Cryo-EM platform for structural analysis
Research Infrastructure
Composed of expert personnel covering all areas of X-ray crystallography and Cryo-EM, with the capability to independently perform the entire process of structural research
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Structural Biology
- Structural analysis using X-ray crystallography and Cryo-EM
- Conducts structure- and mechanism-centered convergent research on various biomacromolecules including proteins, membrane proteins, protein–drug complexes, amyloids, and viruses
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X-ray Crystallography
- Crystallization screening and optimization of proteins and protein–ligand complexes
- Collection of X-ray diffraction data and structural interpretation at the atomic level
- Bio-SAXS measurement and analysis
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Cryo-EM
- Optimization of sample purification and grid preparation
- Operation of high-performance Cryo-TEM and data acquisition
- Single particle analysis, Cryo-electron tomography, helical reconstruction, subtomogram averaging, Micro-ED
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Data Analysis and Computational Structural Biology
- Processing and management of large-scale structure-based data
- Integrated interpretation based on atomic modeling and structure prediction
- Operation of a high-performance computing environment
Recent research achievement in protein structure research (2026): Elucidation of the electron transfer network through the Cryo-EM structure of the Fdh3 protein complex.
Published in Nature Communications, IF=15.7, top 10% in JCR.
