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공지사항 < 알림마당
전문가 초청 세미나 개최(2005. 9. 6)
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| 이름 : 최고관리자 | 작성일 : 2005.09.06 11:11 | 조회수 : 33248 |
| 춘천센터에서는 아래와 같이 세미나를 개최하고자 하오니 관심있으신 분들의 많은 참여바랍니다. - 아 래 - 1. 제목 : Regulation of cell migration and cell-cell adhesion by putative lipid rafts-modulating protein 2. 일시 : 9월 6일 (화요일) 오후 5시 3. 장소 : 춘천센터 세미나실(104호) 4. 연사 : 이해진 박사 5. 소속 : 강원대학교 산학협력단 Abstract : Plasma membrane-cytoskeletal organization is not only static compartment but highly dynamic platform for juxtapostional morphogenesis or communication between cell and cell or cell and environment, such as cell migration, cell-cell adhesion, dorsal closure and directional cell division. Highly dynamic reorganization of plasma membrane and cytoskeleton can be modulated by emerging lipid rafts-modulating proteins in response to external cues. Structural analysis of Annexin II, a calcium-dependent anionic phospholipid binding protein, revealed that membrane binding surface of the annexin had several cationic patches for binding to PtdIns(4,5)P2, by which the annexin may induce clustering of PtdIns(4,5)P2 in a calcium-dependent manner, remodeling of lipid rafts, and thereby, reorganization of membrane-cytoskeleton. Localized reorganization of lipid rafts may break a symmetry in cell membrane and may play roles in polarized cellular processes, including development, directional migration, and cell-cell adhesion. Time-lapse cell imaging and SPR(surface plasmon resonance) measurement demonstrated that annexin II binds specifically to PtdIns(4,5)P2. Imaging study using partial dominant negative mutant annexins unable to bind to PtdIns(4,5)P2 showed that annexin II may play a crucial role in regulating cell polarity in SDF1-induced chemotactic T cells and cell-cell adhesion in epithelial cells. |
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