Multi-Modality Integrated Research Unit
- Establishment of a next-generation multimodal biosignal analysis platform based on the integration of multidimensional molecular information, and conduct of precision biomedical diagnosis and prediction research
Research Content
- Provision of an innovative foundation for elucidating the pathological mechanisms of intractable diseases and evaluating the efficacy of next-generation pharmaceuticals through an integrated analysis platform of spatial and functional information based on multi-omics and imaging technologies such as mass spectrometry imaging (MSI), Raman imaging, stable isotopes, and HR-MAS NMR
- Development of multimodal data integration (Data Fusion) algorithms and conduct of research on discovering disease-specific “Multimodal Biomarker” panels from complex biosignal patterns using AI
Single-tissue spatial omics/drug distribution analysis based on MSI-Raman-HR-MAS.
Discovery of multi-biomarker panels based on integrated multimodal data information
Research Infrastructure
Ultra-high-resolution molecular mapping based on the MS-CARS-Raman convergent platform
- Elucidation of the quantitative spatial distribution of therapeutic drugs and biomolecules in tissues at ultra-high resolution by combining the chemical precision of mass spectrometry with the spatial resolution of Raman imaging
- Analysis of the spatial distribution of proteomes, metabolites, and drugs in tissues and cells
MS-NMR convergent chiral analysis technology
- Analysis of the optical properties and structures of chiral metabolites and pharmaceuticals based on NMR recognition/discrimination using chiral selectors and chiral selective separation by LC–MS/CE–MS
- In vivo pharmacokinetics (PK) / pharmacodynamics (PD) analysis
Biological stable isotope analysis technology
- Elucidation of isotopic regularities in various physical, chemical, and biological systems
- Elucidation of bio- and pharmaceutical response mechanisms and tracing of disease origins through analysis of CNO stable isotope ratios
9.4T FT-ICR MS
CARS-Raman
700MHz FT-NMR
GC/LC/CE-MS
IRMS
Configuration diagram of the multimodal biosignal platform infrastructure for precision biomedical research
