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Equipment Introduction

The Cryo-Electron Microscope System can identify three-dimensional structures at the quasi-atomic level of a very small rapidly frozen monomolecular samples. It is essential for understanding the interaction between major pathogens such as high-risk viruses and host proteins, three-dimensional structural analysis such as membrane proteins and large protein complexes, and research on new drug development targeting interactions between proteins.

Representative Research Case

Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel, Science Advances, 2020. (IF: 13.116)

The ultra-low temperature electron microscope technique is an analytical technique designed specifically for the structural observation of biometric samples such as proteins, which were impossible to observe due to general electron microscopy analysis. The high-resolution three-dimensional structure of cell junction channel proteins involved in intercellular communication has been identified.

Representative Research Papers

• Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel,
  Science Advances, 6:1-15, 2020. (IF: 13.116)