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Representative Research Publications

Observation of gliblastoma and microglia interaction and drug testing using 3D microfluidic cell cul 2021 > Representative Research Publications > Research Results Home

Observation of gliblastoma and microglia interaction and drug testing using 3D microfluidic cell culture platform

  • Theranostics / September 2021
  • Soohyun Hong(First author), Won Jong Rhee, Jeong Ah Kim(Corresponding author)

Research Summary

Understanding the regulation of the crosstalk between human GBM and microglia may help develop effective therapeutic strategies for brain cancer. In this study, efficient delivery of microRNA (miRNA) via extracellular vesicles (EVs), and their intracellular communications was used for therapeutic applications in GBM treatment. We evaluated miR124 EV-based therapeutics in more complex GBM tumor microenvrionment models in vitro using a 3D microfluidic device. The EV-based miRNA delivery combined with the microfluidic technology would expand our understanding of the role played by miRNAs in the GBM microenvironment involving tumor and immune cells.

Expected Outcomes

The 3D microfluidic technology for mimicking tumor microenvironment that interact with immune cells will be utilized as a useful tool to more accurately evaluate new drugs for brain cancer treatment.

Related Figures

  • [Figure 1] Schematic illustration showing overall experimental strategy for GBM and microglia anti-cancer therapy using a 3D microfluidic chip[Figure 1] Schematic illustration showing overall experimental strategy for GBM and microglia anti-cancer therapy using a 3D microfluidic chip
  • [Figure 2] Intratumoral infiltration of NK cells, induced by extracellular vesicle-based drug in a tri-culture system[Figure 2] Intratumoral infiltration of NK cells, induced by extracellular vesicle-based drug
    in a tri-culture system

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